Scroll down past the videos for the testimonies of many victims who have experienced the contagious shedding phenomena. Facebook deleted a group of 120K posting about Adverse Vaccine Events. (Story)
|By Mike Adams Naturalnews.com|
|The vaccine is the bioweapon. Specifically, the spike protein is the bioactive weapon, and it is designed to spread from person to person, being transmissible from the vaccinated in order to infect the unvaccinated.
People who are injected with the mRNA vaccine are having their bodies turned into bioweapons factories, churning out spike protein particles which they shed through their mouths and skin, infecting everyone around them. The spike protein is biologically active and causes blood clots, leading to strokes, heart attacks, pulmonary embolism and infertility effects.
We’ve finally figured out the exact mechanism of how this vaccine is designed to achieve global extermination. It’s called a “self-replicating vaccine” because the vaccine spreads like a virus and infects everyone.
P.S: I’ve also posted an interview with Dr. Lee Merritt discussing how forced vaccines are a Holocaust-level crime against humanity.
Spent the day around several vaccinated people and I’m now up sick in the middle of the night.
Had a small gathering today for my son, who’s leaving for the military. His grandparents and a couple of his friends, who are all four just recently vaccinated, were there. We spent a total of three hours together. Two had the moderna and two had the Jnj. I spent more time near the two with the moderna, than the other two.
My symptoms right now, are nausea and vomiting, and diarrhea. I’ve taken my temp and it’s normal, but I’m going through sweats and chills. I’ve had 3 hours of sleep. I’ve got horrible dry mouth. Went to bed feeling nauseous and woke up drenched in sweat. I barely ate yesterday as I was busy all day, so I am not sure where the upset stomach is coming from.
I’m miserable, and now have horrible anxiety on top of it. I’m on the verge of tears. I hate this world we live in. I’m tired of this shit going on. I pray to god I’m ok. This shit is not fair. I’m sorry to everyone who’s dealt with this damn nonsense this last year. I’m sorry to those who have gotten sick, and those who’ve watched loved ones pass.
My birthday is May 2nd, I’ll be 42 years old and I never thought I’d ever see the world go to hell in my lifetime. Never thought I’d be awake at 4:30 am, sick, crying, and worried something might be wrong with me because SOMEBODY ELSE got a vaccine.
Lord please help this earth we live on…
Edit: I’d also like to add, my son told me today that he of course, has to get a vaccine this next week before he ships out, and in this present moment as I sit here up sick in the middle of the night, I am worried for my son. I’ve held my shit together this last year and I’m not handling shit well at all right now. I’ve already lost one child as an infant. The thought of my son having something happen to him over a vaccine, has me losing my damn shit right now. Nothing like being a mom and can’t even protect your children from this shit ass world we live in. Sorry you guys, I’m really damn upset.
Edit again: sitting here thinking how I wish I could had posted this on the anxiety sub, considering I feel like I’m having a mental breakdown right now. I have PTSD from my daughter dying at 3 months old. Talking seems to be the only thing that helps with my anxiety is on 10. But you can’t post your true feelings about the vaccine anywhere else on reddit without being ridiculed over it if you don’t agree with them. You have all made this sub (besides the shills) a safe haven for people like myself. Thank you.
Hundreds Of More Testimonies of adverse events and deaths…. that are very well done. LINK
By: Dr. Ariyana Love
A vitally important panel discussion was held on April 22nd with a group of leading medical experts who are deeply concerned for the continued existence of the human species. There is now an official consensus among the experts that Covid-19 shots are bioweapons, something I’ve been reporting on from the beginning.
In the latest episode of Critical Thinking, Dr. Sherri Tenpenny, Dr. Carrie Madej, Dr. Larry Palevsky, Dr. Christiane Northrop, Dr. Lee Merritt and Paediatrician Maurine McDonald, expose the hard core truths about Big Pharma’s Covid-19 extermination by genetic experimentation.
Due to the severity of the situation, I transcribed all of the key points made during this discussion so that medical professionals, international bodies, journalists and researchers worldwide can study the material carefully and share it more widely.
The terrifying focus of the discussion was on medical reports which demonstrate that transmission of the Covid bioweapons is taking place from the vaxxed to the unvaxxed. Those who did not subject themselves to Big Pharma’s experiment are getting infected anyway. Even though men and women did not take the deadly jab, they are being sterilized without direct physical contact to a vaxxed person.
Self spreading vaccines is no myth. Page number 45 from this PDF produced by Johns Hopkins University demonstrates that self-spreading vaccines do already exist.
Self-disseminating vaccines for emerging infectious diseases has existed since 2016, according to this study by the US National Library of Medicine National health Institute.
Pfizer officially admits in their own documents that the experimental mRNA trial subjects are Super Spreaders who transmit disease to the unvaxxed. During Pfizer’s clinical trials it’s cleverly termed “occupational exposure”.
Please also read: “World Medical Doctors Warning: Stay Away From The Vaxxed!”
This technology is immorally infecting the unknowing unvaxxed population who have unintentional contact with the mRNA vaxxed. This is a blatant violation of the Nuremberg Code from 1947 and is further evidence that experimental mRNA injections for Covid-19 are in fact genetic biowarfare. This comes straight out of the Pfizer BioNTech study (PF-07302048) titled “A Phase 1/2/3 Study to Evaluate the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against Covid in Healthy Individuals.”
So now the “vaxxed” mRNA injected individuals are the true super spreaders. Pfizer had complete prior knowledge that transmission occurs from the vaxxed to the unvaxxed and therefore this genocide was intentionally planned.
People need to understand that the masks, swab “tests” and injections all contain lethal bioweapons without your Informed Consent. These weapons cut your life short by causing Prion Disease and blood coagulation which is leading to clotting. The Covid-19 injection from Pfizer has been confirmed to cause brain damage and neurodegenerative disease. These are weapons of war for depopulation.
Experts believe that transmission from the vaxxed to the unvaxxed is airborne. Doctors are seeing sterilization, miscarriages and other strange bleeding and clotting in women, men and children exposed to the Covid vaxxed. Transmission is occurring without direct physical contact, therefore the expert consensus now is that the vaxxed should be quarantined immediately. They should at least be wearing a yellow badge out in public so the unvaxxed can identify them and steer clear.
Another important point made by the medical panel is that the vaxxed are not “shedding” as we earlier thought. Shedding is a common phenomenon which usually happens after vaccination but these are not vaccines. Covid shots are a form of gene therapy however the “therapy” part has been inverted because the messenger RNA technology is not programmed for healing but for cell destruction. Therefore, we are dealing not with “shedding” but with bioweapons transmission, the panel makes clear.
Pfizer whistleblower Dr. Michael Yeadon has warned us about the looming extermination of the human race. He estimates those who were injected in Big Pharma’s Biotech experiment have one or maybe two years maximum, to live. He informs us that each additional Covid shot reduces the life expectancy even more. I pointed this out in a previous article after industry insider Dr. Geert Vaden Bossche issued a world public health emergency warning and called for an immediate halt to the Biotech experiment.
You have only to look at the latest Adverse Events and Deaths reported to VAERS to know that death and injury from the Covid shots are far worse than the Corona virus, which is no more deadly than the seasonal Influenza flu.
Vaccination vs Transfection
A normal vaccine injects a pathogen into your blood stream to evoke an immune response whereby your body produces antibodies to the disease. Never has a vaccine inserted anything directly into human cells before.
The Covid shots are raping the human being by a process known as biohacking. Messenger RNA (mRNA) and adenoviruses are being directly deposited into your cells for genetic reprogramming using a lipid-nanotechnology delivery system. None of these Biotechnologies have ever been tested on humans before and now they are being used worldwide without Informed Consent of the ingredients or Adverse Reactions.
Learn more about biohacking here: The Corona Jab Serum & It’s Effects On Human DNA & Brain Hacking! Are You Ready To Blow Your Mind?
Synthetic and foreign RNA is being fused to your tissue through the use of semiconducting Hydrogels and literally changing forever what it means to be human. This process of genetically modifying the human race and creating a new species of hybrid humans, is called transfection not vaccination. Big Pharma, mainstream media, government and leading health authorities are lying to us because this is not vaccination.
Worse yet is that the cells of the Covid vaxxed are being programmed to produce the synthetic spike protein of the pathogen they were injected with. So their bodies are now pathogen creators and they are transmitting the disease to others. It’s unclear whether this pathogen production ever stops. Production of this disease by your own cells, causes the immune system to produce antibodies to the spike protein. This triggers the body of the vaxxed to attack itself.
Do you understand what you have an immune system for? Your immune system is there to identify pathogens and attack them so they don’t harm you. How on God’s green Earth could injecting a pathogen into your cells and programming your cells through genetic engineering, to produce that synthetic pathogen in the form of a spike protein, be a good thing?
We are just discovering that Big Pharma only needed to inject part of the population with their bioweapons experiment in order to sterilize the rest of the population and exterminate the majority, potentially.
These doctors on the front lines are now sharing testimony of transmission from the vaxxed to the unvaxxed. The Biotech infected person can now infect anyone. They are a danger to us all and must be quarantined at once.
The billionaire predators like Bill Gates, Klaus Schwab, Anthony Fauci and those who perpetrated this genocide on mankind must be restrained by their necks and stand trial.
Please note that the nanotechnology medical devices being used in the Covid shots have a shelf life of two years. This is most likely why the Biotech industry want to inject the population year after year.
SUDDEN DEATH of 32 YEAR OLD
This couple’s step-son, age 32, died from a heart attack 12 hours after getting the Johnson & Johnson Vaccine. Coroner refuses to release reports; calls cause of death “inconclusive.” A lot of these deaths are simply being covered up. Here’s the family to tell you:
Bombshell Salk Institute science paper reveals the covid spike protein is what’s causing deadly blood clots… and it’s in all the covid vaccines (by design)
The prestigious Salk Institute, founded by vaccine pioneer Jonas Salk, has authored and published a bombshell scientific article revealing that the SARS-CoV-2 spike protein is what’s actually causing vascular damage in covid patients and covid vaccine recipients, promoting the strokes, heart attacks, migraines, blood clots and other harmful reactions that have already killed thousands of Americans (source: VAERS.hhs.gov).
Critically, all four covid vaccine brands currently in widespread use either inject patients with the spike protein or, via mRNA technology, instruct the patient’s own body to manufacture spike proteins and release them into their own blood. This floods the patient’s body with the very spike protein that the Salk Institute has now identified as the smoking gun cause of vascular damage and related events (such as blood clots, which are killing many people who take the vaccines).
Put simply, it means the vaccines were designed to contain the very element that’s killing people.
The false assumption of the vaccine industry and its propagandists is that the spike protein is “inert” and harmless. The Salk Institute proves this assumption to be dangerously inaccurate.
Salk Institute: The spike protein “damages cells” and causes “vascular disease” even without a virus
In an article entitled, “The novel coronavirus’ spike protein plays additional key role in illness“, published on April 30th, 2021, the Salk Institute warns that, “Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease.”
From that article:
Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself.
The paper, published on April 30, 2021, in Circulation Research, also shows conclusively that COVID-19 is a vascular disease, demonstrating exactly how the SARS-CoV-2 virus damages and attacks the vascular system on a cellular level.
“A lot of people think of it as a respiratory disease, but it’s really a vascular disease,” says Assistant Research Professor Uri Manor, who is co-senior author of the study. “That could explain why some people have strokes, and why some people have issues in other parts of the body. The commonality between them is that they all have vascular underpinnings.”
…the paper provides clear confirmation and a detailed explanation of the mechanism through which the protein damages vascular cells for the first time.
In the new study, the researchers created a “pseudovirus” that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal model—proving that the spike protein alone was enough to cause disease. Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls.
The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. They showed that the spike protein damaged the cells by binding ACE2. This binding disrupted ACE2’s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented.
Previous studies have shown a similar effect when cells were exposed to the SARS-CoV-2 virus, but this is the first study to show that the damage occurs when cells are exposed to the spike protein on its own.
“If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID,” Manor explains. “Further studies with mutant spike proteins will also provide new insight towards the infectivity and severity of mutant SARS CoV-2 viruses.”
The article does not mention that covid-19 vaccines are injecting patients with the very same spike protein that was studied, but this fact is widely known and even touted by the vaccine industry.
The upshot of this research is that covid vaccines are inducing vascular disease and directly causing injuries and deaths stemming to blood clots and other vascular reactions. This is all caused by the spike protein that’s deliberately engineered into the vaccines.
From the medical journal Circulation Research: The spike protein is what’s causing the damage
The Salk Institute article refers to this science paper published in Circulation Research: SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2.
This paper is the first to document the mechanism by which spike proteins — even ones lacking an active viral component — cause vascular destruction by binding to ACE2 receptors and inhibiting the function of cellular mitochondria.
From the paper:
SARS-CoV-1 [Spike] protein promotes lung injury by decreasing the level of ACE2 in the infected lungs. In the current study, we show that S protein alone can damage vascular endothelial cells (ECs) by downregulating ACE2 and consequently inhibiting mitochondrial function.
Also from the paper:
We next studied the impact of S protein on mitochondrial function. Confocal images of ECs treated with S1 protein revealed increased mitochondrial fragmentation, indicating altered mitochondrial dynamics…
Moreover, ACE2-L overexpression caused increased basal acidification rate, glucose-induced glycolysis, maximal glycolytic capacity, and glycolytic reserve (Figure [D], ii). Also, ECs incubated with S1 protein had attenuated mitochondrial function but increased glycolysis, when compared with control cells treated with IgG…
…our data reveals that S protein alone can damage endothelium, manifested by impaired mitochondrial function and eNOS activity but increased glycolysis. It appears that S protein in ECs increases redox stress which may lead to AMPK deactivation, MDM2 upregulation, and ultimately ACE2 destabilization.
The study, obviously authored by a pro-vaccine organization, then says that “vaccination-generated antibodies” may protect the body from the spike protein. Thus, the paper is essentially saying (paraphrased): “The spike protein may cause enormous damage to the vascular system when a person is injected with that spike protein, and when that person’s immune system attacks the spike protein and neutralizes it, the damage may be halted.”
In other words, the human immune system is trying to protect the patient from the damage caused by the vaccine, before the patient is killed by the adverse reactions.
Put another way, any person who actually survives the covid vaccine only does so because their innate immune system is protecting them from the vaccine, not with the vaccine. The vaccine is the weapon. Your immune system is your defense.
All covid vaccines should be immediately halted and recalled
Based on this research alone, all covid vaccines should be immediately pulled from the market and reevaluated for long-term side effects.
According to government published VAERS data, vaccine deaths in 2021 (so far) are already nearly 4,000% higher than all the vaccine deaths of 2020, combined. What’s new in 2021? The covid vaccine, built with the spike protein that causes vascular damage. The number of Americans who died after taking covid vaccines is already in the thousands, and realistic estimates put that number at tens of thousands (with more dying each day).
The mechanism is now well understood: The covid vaccine injects the patient with spike proteins, the spike proteins proceed to cause vascular damage and blood platelet aggregation, this leads to blood clots which circulate around the body and lodge in different organs (the hart, lungs, brain, etc.), causing deaths that are attributed to “strokes” or “heart attacks” or “pulmonary embolism.”
The common cause is the vascular damage stemming from the spike protein. In essence, millions of people are being injected with artificial blood clotting factors and then dying from blood clots, all while the disastrously dishonest corporate media claims all covid vaccines are completely “safe” and have harmed no one.
mRNA vaccines turn your body into a spike protein bioweapons factory to expose others
mRNA vaccines transform the human body’s own cells into spike protein factories, spilling deadly spike protein particles into the bloodstream. A growing number of researchers are also finding that these spike proteins appear to be “shedding” or transmitting from the vaccinated to the unvaccinated, causing adverse reactions in people who were never vaccinated themselves, but who have spent time close to other people who were.
The technology behind this is called “self-replicating vaccines,” and it was pioneered by doctors and scientists working under the racist Apartheid regime of South Africa. There, medical researchers designed race-specific, weaponized, self-replicating vaccines that were designed to spread through the Black population of South Africa and exterminate the masses who posed a threat to the ruling technocratic elite. Today, we are all the targets of these weapon systems as globalists seek to exterminate human populations on a global scale, regardless of skin color or country of origin.
Just this year, the Johns Hopkins Bloomberg School of Public Health has celebrated this self-replicating vaccine technology and is calling for it to be used to achieve global mass vaccination, augmented by surveillance drones and AI robots that enforce vaccine compliance (probably at gunpoint).
In effect, mRNA vaccines function as bioweapons factories that turn human beings into biological weapon manufacturing and transmission hubs, spreading vascular damage and death to the entire population, including those who were not yet vaccinated.
All covid vaccines are risky medical experiments, yet the oblivious masses are brainwashed and told the vaccines have all been “approved” as safe and effective
The FDA has not granted therapeutic approval for any covid-19 vaccine, and no long-term trials have been completed to show covid-19 vaccines as safe and effective. Rather, the FDA granted experimental authorization use in the USA, which admits that those who take the vaccines are participating in a risky medical experiment with unknown consequences.
Those who take the vaccine are often brainwashed or deceived by the lying corporate media which falsely claims covid vaccines have been “approved” by the FDA and have harmed no one. The government’s own VAERS data at VAERS.hhs.gov proves otherwise.
In today’s Situation Update podcast, I explain all this in more detail, revealing how covid vaccines were designed from the very start to be depopulation / euthanasia injections to achieve global depopulation (mass murder via vaccines).
This conclusion is now irrefutable. The vaccines literally inject people with the very substance that kills them. This isn’t medicine; it’s medical violence against humanity.
The medical science establishment that pushes vaccines is now engaged in Holocaust-level crimes against humanity. Josef Mengele would be proud. (He was eventually executed by public hanging for his crimes against humanity.)
Listen and share everywhere:
Critically Thinking with Dr. T and Dr. P – Episode 44
Panel Discussion Transcription:
Dr. Larry Palvesky points out that a vaccine is supposed to protect us against a bacterial or viral infection. There is nothing in any of these shots that is designed to protect us against a viral infection. The authorities say this and the patents describe it too that these shots were never designed to protect us against a virus. As soon as we realize that these are not vaccines, we realize that everything after that is a complete and utter lie. The Covid-19 shots were not designed to protect us against a SARS-CoV-2 infection and therefore it cannot stop the transmission from a SARS-CoV-2.
Dr. Larry continues, by saying when we look at the literature from 2020, we see people are getting illnesses of blood disorders, lack of oxygen, hypoxia, lung disease, clotting disease, strokes, hypertension, hypotention, loss of taste, loss of smell and neurological issues. These are not symptoms of a virus illness. This was a clinical presentation of the poisoning of the blood, he says. All the literature shows that the spike protein of this virus was responsible for causing all of these symptoms; brain and neurological problems, heart disease, clotting factors, loss of oxygen, loss of taste and smell, hypertension and hypotension. The spike protein was responsible for causing the diseases that we saw. This spike protein is not a naturally occurring thing, it is a man made weapon. It is not a virus. It is a part maybe attached to the virus and god knows what else, that started the ball rolling in getting people sick. This was never an Influenza-like or flu-like disease. It was straight up a poisoning of the blood. This spike protein could attach to receptors in all parts of the body; brain, heart, lungs, kidneys, intestines, sperm and female reproductive system.
So why in God’s name are we all ok with injecting something into the body that’s going to cause all of us to make spike protein? The very part of the so called weapon that was creating the illness and the group of symptoms in the first place! This is not a vaccine! Now, if your body is being given the genetic material to make a synthetic spike protein, we have absolutely no idea what the body does when the genetic instructions get into the cells and start making spike protein.
Dr. Tenpenny has found the real possibility that there is other foreign RNA inside these Covid shots. We really have no idea what’s in these shots. We think it’s spike protein Dr. Larry continues but we generally have no idea. If we go on the fact that it’s a spike protein that is being manufactured in the factory by the cells of the human body and that we know that maybe if our own Messenger RNA is in our cells we would turn it off ourselves. But we have no experience using an injected synthetic messenger RNA genetic instructions as to whether or not our bodies are going to turn that on or turn it off after our bodies start the factory production of spike proteins. So there’s zero evidence or scientific studies as to whether that spike protein turns on and stays on or ever turns off. And we have no evidence if the body that’s been injected and now making the spike protein, is exhaling it through the lungs, spitting it out through saliva, urinating it out through skin or putting it out through gas or stool.
What we have is a massive, brilliant propaganda of genocide because they don’t have to inject everyone to get the results that they’re looking for because now we see that those people who are getting injected are actually the lepers, are actually the pariahs and making healthy people that have never been injected get Covid-19 symptoms, bleeding, miscarriages and deaths.
This is not a vaccine, please stop calling it a vaccine. Lipid-nanoparticles have never been used in a vaccine before. They are capable of passing any material that’s attached to it (with a drug payload) into the brain, lungs, liver, sperm and female reproductive systems. We are in a crap shoot. This is Russian Roulette. We have no answers about what is being transmitted or how it’s being transmitted and we should be up in arms! The genie is out of the bottle. This is genocide. This is a weapon of mass destruction and it’s requiring us to speak up. There is something being passed from people who were shot up with this poison to others who’ve not been injected. We really need to start calling for those who’ve been injected with the Covid poison to be quarantined and have them wearing a badge on their arms showing they’ve been vaxxed so we know to avoid them on the street and to not go near them.
Dr. Sherry Tenpenny has identified 20 mechanisms of injury with the Covid shot. The mechanism of these Covid shots is to force our cells to make a spike protein and make an antibody to the spike protein. The spike protein can bust through the blood/brain barrier. The spike protein itself can manipulate your genes and modify proteins in your brain and cause pulmonary hypertension, cardiovascular problems and it’s a lethal weapon, says Dr. Tenpenny. 89 other Covid shots are almost ready to be injected into humanity.
The Johnson & Johnson shot is an adenovirus shell that has a genetic material called a transgene on the inside of it. 50 billion little particles of adenovirus get injected into your arm. Adenovirus is a common cold virus. Dr. Tenpenny suspects that part of the biggest transmission process is coming from the J&J adenovirus that migrates into the lungs and is breathed out. They’re already creating intra-nasal Covid shots to attach to your olfactory nerves in your nose and deliver the genetic material directly into your brain.
Do not call the Covid shots vaccines any longer. Start auto-correcting and teaching others around you to do the same. It’s a shot or an injection of foreign genetic material. Because whenever you say the word vaccine people think it’s just like a flu shot. We also must stop using the term shedding and replace it with transmission.
It’s also possible as Dr. Carrie Madej suggested that the spike proteins are activated by 5G and resonate differently and maybe that’s how transmission is happening. So it’s possible too that it has EMF (Electromagnetic Frequency) type properties.
The main topic of urgent concern is the transmission of the Covid bioweapons from the vaxxed to the unvaxxed, infertility and integrity of the blood supply.
Shedding occurs with vaccination. Since Covid-19 is not a vaccine but a form of gene therapy using messenger RNA, this is not shedding. We’ve always connected shedding with live viruses, like when you have the flu or coughing with something, or the polio vaccine, rubella vaccine or chicken pox.
We’ve already made the distinction between the Covid-19 shots and vaccines and determined these are not vaccines. With a vaccine, you’re injected into your blood stream with a pathogen. This induces an immune response and the production of antibodies. Covid-19 is an experiment using a foreign Messenger RNA (mRNA) and a slew of other synthetic drugs and medical devices (nanotech) which penetrate the cell membrane, program DNA and cause cell death or autoimmune Prion Disease.
There is nothing about the Covid-19 shots that’s even comparable to a vaccine. The nanobots are programming your cells to produce a spike protein which is untested and foreign to the human body. The antigen immune response that gets triggered is nothing like vaccination. The antigens cause blood clotting (coagulation) which has been leading to many deaths.
This is not shedding. What’s being transmitted from the vaxxed to the unvaxxed. Let’s change our language and refer not to shedding but to transmission. This is an unprecendented situation. Something is transmitting between the vaxxed to the unvaxxed.
Dr. Lee Merritt explains that medical experts are receiving thousands of reports from around the world of menstrual irregularities and reproductive dysfunction following the Covid injection, while media is focusing on blood clots. Women are bleeding for weeks, some are not getting their period and post menopausal women are bleeding. Blood clotting is being reported and clotting during pregnancy. There are miscarriages and bloody noses. Children in close proximity to the vaxxed are having significant nose bleeds. There’s bruising on the legs and blood clots in men. We are seeing things that make no sense and opening up the discussion. There is unprecedented censorship, something we’ve never seen before. Entire Dicidual Casts are coming out of women, where entire parts of the uterus is shedding off.
Polysorbate 80 which is included in the Covid shots can shut down ovarian function. In men, doctors are seeing swelling of the genitals, erectile dysfunction, scrotum swelling and breast irregularities in women.
There’s no formal database for people around those who’ve been injected. Thus consensus is that people were injected with bioweapons and their bodies are now secreting and transmitting to others. This is not a normal immunization. It causes your body on a cellular level to produce the SARS-CoV-2 synthetic protein that has never been seen. The body starts to produce this like a factory that does not shut off. The cells of the vaxxed are now producing the pathogen they were injected with. Essentially the vaxxed is producing the bioweapons their cells were coded for which is transmissible to the unvaxxed. Theoretically, the biological agent can be in the vaxxed saliva, urin, fecus, sweat, seminal fluid, blood and flatus. It’s coming out of their bodies and transferring to others in office settings which has caused miscarriages, inability to get pregnant and heavy bleeding. Something is being produced by the body of the vaxxed which is adversely affecting others, Dr. Merritt explains.
Dr. Carrie Madej mentions Nano-lipid particles and the Hydrogel. That substance can do many things, she says. The drug manufacturers are telling us that the human body is very intelligent and would naturally destroy the synthetic codes being injected into people by Big Pharma. So they figured out a way to trick our bodies to not attack the synthetic code. Nano-lipid particle is an “on demand drug delivery system”. It suppresses our immune checkpoints so it can penetrate the cell membrane to deliver the drug payload. On demand, it can be triggered at any moment to deliver the payload. It can be used for biosensors in the body and it has the ability to accumulate data from your body, transmit and receive energy, messages or frequencies and impulses. It can react to things around you. Something foreign in our bodies. EMF from 5G antenna (for example). It produces it’s own voltage. Radiation and EMF toxicity has been steadily increasing in recent times and the amount of radiation that transfers through our cell phones has also increased.
Dr. Lee Merritt is an orthopedic Surgeon, trained by the US Navy. She says, we are not just seeing bleeding problems but transmission. She asked Dr. Judy Mikovitz about that. Normally a portion of a virus (spike protein) is not transmissible. Normally viruses go out through the cells. This isn’t the full virus only a spike protein pathogen head in your cells. So could it be airborne? That’s a possibility. Fecal/oral transmission is also a common way for viruses to transmit.
A Prion is a misfolded protein. The way they weaponized the spike protein is they inserted a gene into the spike protein that allows it to have a foreign cleavage. That can be changed confirmationally to combine with your Ace2 Receptors. So what you’re talking about is an artificial 3D confirmation which sounds a lot like a Prion. And those things are a self-replicating protein that can be transferred through serum for sure. We don’t know how else it’s transmitted.
The biolipids encasing the RNA is called “Matrix M”. It turns out that the Matrix M also has the adjuvant. By itself it can tune up your immune system even without a pathogen. Part of the adjuvant is from a bark in the South American tree called the Quillaja saponaria. They’re called saponins. When Dr. Merritt looks back at the original research of the development of Matrix M, they talk about the problem of bleeding. It strips erythrocytes of their hemoglobin. It changes the confirmation of erythrocytes, damages the endothelium and causes lymphocyte destruction.
Transmission is the issue now. Dr. Lee Merritt thinks the spike protein itself could be transmitted based on a study she conducted. In a two month period she pulled out 358 cases from VAERS of strange blood/bleeding phenomenon and thrombocytopenia; abnormal menses, clots and large amounts of bleeding and unusual menses. Then all sorts of bleeding problems like brain bleeds, GI bleeds, weird bleeding from an old scar, boil wounds, skin bleeding and men oozing blood from the legs. We’re seeing very rare conditions. Dr. Merritt thinks it’s from the spike protein. We’re dealing with two different technologies she says, DNA tech and RNA tech and the bleeding started early on.
Paediatrician Maurine McDonald pointed out that children were never in any danger of contracting Corona virus’. Medical professionals are seeing children having symptoms like blood clotting and nose bleeds after being around the Covid vaxxed.
Editors note: infants have died after breast feeding from their vaxxed mothers.
Solutions & Treatments
Dr. Tenpenny gives some interesting facts about two very safe and effective treatments for Coronavirus and Influenza which has been suppressed in the mainstream.
Ivermectin has no side effects or complications and it’s been used for over 60 years. Hydroxychloroquine (HCQ) has been used for over 70 years. Ivermectin and HCQ work against viruses by two different mechanisms of action:
1. HCQ binds to the sigma one and sigma two proteins.
2. Ivermectin blocks the spike protein, globs onto the spike protein which is the crown of the virus, while in circulation and globs onto the spike protein on other Corona viruses. It also blocks the binding to the Ace Receptors on the surface of all your cells. It also has some anti-inflammatory properties.
Dr. Tenpenny suggests putting people on both HCQ and Ivermectin when they’re sick and America’s Frontline Doctors are prescribing these medicines across the USA.
You need to know what your Vitamin D level is. Indonesians worked out that if your Vitamin D level is greater than 30, you have less than a 4% chance of ending up in intensive care from Covid. Dr. Tenpenny thinks your Vitamin D level should be therapeutically between 80 and 100. Also, get a Zinc level tested. It should be between 11 and 12. Take Quercetin which is a plant based anti-oxidant which drives the Zinc into the cells. There is a long list of other things you can do to protect yourself.
Dr. Tenpenny believe’s transmission could be airborne like the andenovirus. If it’s airborne, she suggests to use colloidal silver every day.
Do whatever it takes to keep your immune system healthy. We are swimming in germs all the time and that’s what boosts immunity but now we are swimming in bioweapons which have been unleashed on the entire Earth.
Maureen McDonald reminds us about vibrational frequency. Remaining in a positive mind set and staying out of fear is essential in these times. Tones can change DNA and meditation.
Dr. Northrop recommends taking a bath in half a liter of organic soap, like laundry soap and alfalfa pellets or hay, what you buy for your hampsters. If you have a black light you can see the Hydrogel Nanoworms come out of your body and go to towards the alfalfa. Then take a shower in Dr. Bronner’s soap. With gloves on, take the stuff out of your bathtub and deposit it into the bag with the gloves. AI particles thrive on negativity. This is a war between good and evil. Bring in the Christed light and love. This is our moment. Our fertility as a human race is under attack and we need to resist. You do that not by getting into doom and gloom but by through inspired action. Come together and get the word out beyond the censorship. We are starting a data base on those infected by second hand transmission.
Dr. Larry says to isolate yourself from the vaxxed. People who’ve not gotten the shot need to get together in person. One of the reason for the lockdown is to prevent people from congregating and amassing enough strength and rebellion. One of the reasons for the mask is the same, to keep people apart.
Stand for Health Freedom, Make Americans Free Again and doctors for world ethic like World Doctors Alliance, are bringing people together. People need to start mobilizing and giving each other strength from the core of our being. I think our leaders are not our leaders, Dr. Larry continues. We have lost our government. We are not being governed, we are being ruled. We have lost our courts, Congress, media, medical institutions and we lost the people who are supposed to be helping to protect us. We have to stop asking those people to protect us and we need to take the protection onto our own shoulders and that requires us to turn to where the power really is and that’s in our own authority and amongst individuals who are awake and trying to be awake.
Dr. Madej suggests we get together once a week. She has a project called Freedom Meetup and they help you to start a group in your area. Love frequency from the heart extends out 5 feet according to Heartmath scientific research. This is a frequency war says Dr. Madej and a battle between good and evil. Meeting and making food together, laughing, hugging, kissing, singing and dancing brings your vibrations up. Spend two hours a week doing this and it will spread to others. What we’ve read about in the Book of Revelations is here now. Do not be afraid because we are the ones with the power. We’ve been lied to about reality, lied to about who we are, where we came from and what we are here for. So don’t let the panic get to you. There’s no bioweapons I’ve ever seen that is that strong. We are amazing spiritual beings who learn how to adapt and overcome. This is no different. It’s a hard war because it’s in our minds and we have to realize that. You cannot depend on any one magic person to come and rescue us. The government is gone. Our Executive Branch answers to FEMA (Israel). Our medical industry sadly took a very dark turn especially in the last 5-10 years.
Dr Madej recommends Banzonite Clay baths which work against radiation.
Dr. Merritt then mentions how there is a small group of people at the top running this show, pulling the strings and organizing this genocide. She quotes something very interesting from the Policy For The New American Sensory (2002), written by the US Defense insiders like Michael Chertoff, Dick Cheney and the usual suspects:
“Advanced forms of biological warfare that can target specific genotypes may transfer biological warfare from the realm of terror to a politically useful tool”.
You’re not going to stop psychopaths with arguments or good feelings. At some point we have to take down the industrial organization that is bringing it to us. If we had known about the Schwerin Barbering Plant in Germany in WW2, that was the lynchpen that if we’d taken it down every German car, tank and plane would have ceased to move. But we did not know that was the lynchpen. They so badly don’t want us to know about treatment, Ivermectin and HCQ because that is the lynchpen that would remove the fear. We have to protect people’s ability to get those medications and pull people out of the psyop of fear.
If they kill off 150 million Americans, there’s nothing stopping China from taking out the rest of us. This is a National Security issue, worldwide. We have to wake up the sheeple and get them to realize they’re coming after your children. People need to self-examine. Are you involved in an industry that’s bringing this to us?
Ms Tiffany closes by asking how in God’s name can governments be talking about vaccine passports with the excessive Adverse Reactions and Deaths from the Covid shots? If you have not heard about these things from this medical panel it’s because all truth tellers are being censored. At the end of the day you have to understand that you have to take responsibility for your own health. If the government removes that ability from you then you don’t have your body anymore. You need to maintain control of your own body and your children’s bodies and make sure everyone else has the ability to do the same. There’s a lot we don’t know, there’s a lot we need to learn and a lot that could be happening with these Covid shots. We may not be able to control everything but we can continue to fight to make sure that we still maintain control of the things that we can control. Pay attention to the legislation that’s happening in your state or country and make sure that you do not allow vaccine passports to happen in private or government agencies, anywhere. Make sure that there’s always a choice and we continue to maintain control over our own bodies.
World Doctors Warning: Stay Away From The Vaxxed!
By: Dr. Ariyana Love
Sterilization and Transmission
We’ve been through a year and a half of enormous stress. Now it’s required of us to stand up and take action to save the future of the human race. Doctors from around the world need to continue speaking out about Covid-19 being an unprecedented biological experiment and an attack on humanity, as well as accelerated genocide.
Thousands of personal testimonies are being shared online regarding COVID-19 Biotech injections that coincides with reported Adverse Reactions, indicating that the Biotech weapons are targeting woman’s reproductive health and sterilizing the population. The unvaxxed are becoming sterilized by the vaxxed through a mechanism of transmission we have yet to understand.
There have been doctors, experts and industry insiders such as Dr. Michael yeadon and Geert Vanden Bossche who’ve been blowing the whistle and warning us of viral shedding from the vaxxed that could infect the healthy. Indeed, people who come in contact with someone who has been vaxxed with the experimental medical devices but who have not been vaxxed themselves, are developing Covid-19 symptoms, including blood clotting, bleeding, miscarriages, rashes and more.
When analyzed further, Dr. Christiane Northrop explains that the “shedding from a vaccine is very different from what we are witnessing with the Covid-19 shot”. Shedding is a natural occurrence from vaccinations but since Covid-19 is not a vaccine, we need to think not in terms of shedding but in terms of transmission.
We finally have irrefutable evidence from Pfizer’s own documents which state that transmission of the deadly Covid-19 poison from both inhalation and skin contact will transmit whatever is in the vax, from the vaxxed to the unvaxxed. Sterility by second hand transmission has always been known by Pfizer and was in fact the goal. This is an intentional sterilization of the population using Biotech weapons.
This video has a compilation of experts giving us vital medical information about the Covid-19 injections.
World Doctors And Nurses Putting Out Dire Warning: Stay Away From mRNA Vaccinated People
Inoculation means “you’ve been injected with cellular technology that carries the mechanism to make a protein from a synthetic mRNA via riobosomes,” Dr. Christiane Northrop explains.
This is a raping of your cells and a forced genetic experiment without Informed Consent of the trial participants and thus violates Nuremberg Codes. Humanity has a duty to shut down Big Pharma’s genocide experiment immediately.
The head of the FDA has stated that his 17,000 employees and himself will not approve or authorize any Covid-19 vaccinations. They have not gone through testing and they have not been proved effective. Severe Adverse Affects are taking place by the minute from this experiment and Deaths are piling up.
Now please listen to this powerful message and synopsis of what is happening, from Nova Scotia, Canada.
“Are you going to continue to follow these Covid narratives or are you going to stand up” asks a citizen’s reporter via MRNA Death Toll Telegram channel.
The following is excerpted from this link.
(By JIm Stone as posted at Beforeitsnews.com)
I am so scared by this my brain is jamming and I am not coding right. I am fixing the coding errors now. Download from original source
THE ELITE HAVE ALREADY FFED OFF TO THEIR HIDEOUTS, THEY HAVE RELEASED THE GENOCIDE READ IT AND WEEP, WE ARE EFFED. PFIZER’S OWN DOCUMENTS STATE BOTH INHALATION AND SKIN CONTACT WILL TRANSMIT WHATEVER IS IN THE VAX FROM THE VACCINATED TO THE UNVACCINATED Here is what just this small portion of this Pfizer document is saying:
1. If a man who was not vaccinated touches a vaccinated woman, or breathes any of the air she breathes, (in other words, walks by her in the office) and he then has sex with his wife, his wife can have an adverse event and she should avoid having children.
2. If a woman who was never vaccinated gets exposed to a woman who was vaccinated, she can:
B: spontaneously abort,
C. poison a baby via her breast milk
D: Have babies that have congitive difficulties.
This is universal, and very bad. Here is a small section of text I translated to English:
22.214.171.124. Occupational Exposure
“An occupational exposure occurs when a person receives unplanned direct contact with a vaccine test subject, which may or may not lead to the occurrence of an adverse event. These people may include health care providers, family members, and other people who are around the trial participant.
When such exposures happen, the investigator must report them to Pfizer saftey within 24 hours of becoming aware of when they happened, regardless of whether or not there is an associated secondary adverse event. This must be reported using the vaccine secondary adverse event report form. SINCE THE INFORMATION DOES NOT PERTAIN TO A PARTICIPANT INVOLVED IN THE STUDY, THE INFORMATION WILL BE KEPT SEPARATE FROM THE STUDY.”
TO CLARIFY: Vaccine study participants become super spreaders of something, they don’t say what it is, but it triggers secondary adverse events in people that never had the vax, when they are exposed to people who did have the vax.
THIS IS SO BAD that right here, in this little bit of quoted text, it warns that un-vaccinated men who have been exposed to a woman who was vaxxed will then pass whatever is in the vax to another woman.
Even the relatively small portion of the document I have put below here says the vax triggers spontaneous abortions and reproductive problems when un-vaccinated people are exposed to the vaccinated and that breast milk from a vaccinated mom can harm the infant. And if anyone does not believe it, then click the link above and wade through that enormous and intentionally confusing document. It’s for real folks, the vax is indeed the kill shot.
Do not permit the vaccinated to come anywhere near you, it is now official.
Here is a small portion of this huge document, straight from pfizer:
Study intervention – A vaccine test subject.
AE – Adverse event in someone who got the vax.
SAE: An adverse event in someone who was exposed to someone who got the vax.
EDP: Exposure during pregnancy
8.3.5. Exposure During Pregnancy or Breastfeeding, and Occupational Exposure Exposure to the study intervention under study during pregnancy or breastfeeding and occupational exposure are reportable to Pfizer Safety within 24 hours of investigator awareness.
126.96.36.199. Exposure During Pregnancy An EDP occurs if:
* A female participant is found to be pregnant while receiving or after discontinuing study intervention.
* A male participant who is receiving or has discontinued study intervention exposes a female partner prior to or around the time of conception.
* A female is found to be pregnant while being exposed or having been exposed to study intervention due to environmental exposure. Below are examples of environmental exposure during pregnancy:
* A female family member or healthcare provider reports that she is pregnant after having been exposed to the study intervention by inhalation or skin contact.
* A male family member or healthcare provider who has been exposed to the study intervention by inhalation or skin contact then exposes his female partner prior to or around the time of conception.
If this vax is not shedding into other people, why would contact between vaccinated and un-vaccinated be an event worth noting? If this vax is not shedding, then WHY does a guy who has been around a vaccinated woman, even if he did not touch her or have sex, need to worry about getting a different woman pregnant?
That’s not all, the following is detailed, and far worse.
The investigator must report EDP to Pfizer Safety within 24 hours of the investigator’s awareness, irrespective of whether an SAE has occurred. The initial information submitted should include the anticipated date of delivery (see below for information related to termination of pregnancy).
* If EDP occurs in a participant or a participant’s partner, the investigator must report this information to Pfizer Safety on the Vaccine SAE Report Form and an EDP Supplemental Form, regardless of whether an SAE has occurred. Details of the pregnancy will be collected after the start of study intervention and until 6 months after the last dose of study intervention.
* If EDP occurs in the setting of environmental exposure, the investigator must report information to Pfizer Safety using the Vaccine SAE Report Form and EDP Supplemental Form. Since the exposure information does not pertain to the participant enrolled in the study, the information is not recorded on a CRF; however, a copy of the completed Vaccine SAE Report Form is maintained in the investigator site file. Follow-up is conducted to obtain general information on the pregnancy and its outcome for all EDP reports with an unknown outcome. The investigator will follow the pregnancy until completion (or until pregnancy termination) and notify Pfizer Safety of the outcome as a follow-up to the initial EDP Supplemental Form. In the case of a live birth, the structural integrity of the neonate can be assessed at the time of birth. In the event of a termination, the reason(s) for termination should be specified and, if clinically possible, the structural integrity of the terminated fetus should be assessed by gross visual inspection (unless preprocedure test findings are conclusive for a congenital anomaly and the findings are reported). Abnormal pregnancy outcomes are considered SAEs. If the outcome of the pregnancy meets the criteria for an SAE (ie, ectopic pregnancy, spontaneous abortion, intrauterine fetal demise, neonatal death, or congenital anomaly), the investigator should follow the procedures for reporting SAEs. Additional information about pregnancy outcomes that are reported to Pfizer Safety as SAEs follows:
* Spontaneous abortion including miscarriage and missed abortion;
* Neonatal deaths that occur within 1 month of birth should be reported, without regard to causality, as SAEs. In addition, infant deaths after 1 month should be reported as SAEs when the investigator assesses the infant death as related or possibly related to exposure to the study intervention. Additional information regarding the EDP may be requested by the sponsor. Further follow-up of birth outcomes will be handled on a case-by-case basis (eg, follow-up on preterm infants to identify developmental delays). In the case of paternal exposure, the investigator will provide the participant with the Pregnant Partner Release of Information Form to deliver to his partner. The investigator must document in the source documents that the participant was given the Pregnant Partner Release of Information Form to provide to his partner.
188.8.131.52. Exposure During Breastfeeding An exposure during breastfeeding occurs if:
* A female participant is found to be breastfeeding while receiving or after discontinuing study intervention.
* A female is found to be breastfeeding while being exposed or having been exposed to study intervention (ie, environmental exposure). An example of environmental exposure during breastfeeding is a female family member or healthcare provider who reports that she is breastfeeding after having been exposed to the study intervention by inhalation or skin contact. The investigator must report exposure during breastfeeding to Pfizer Safety within 24 hours of the investigator’s awareness, irrespective of whether an SAE has occurred. The information must be reported using the Vaccine SAE Report Form. When exposure during breastfeeding occurs in the setting of environmental exposure, the exposure information does not pertain to the participant enrolled in the study, so the information is not recorded on a CRF. However, a copy of the completed Vaccine SAE Report Form is maintained in the investigator site file. An exposure during breastfeeding report is not created when a Pfizer drug specifically approved for use in breastfeeding women (eg, vitamins) is administered in accord with authorized use. However, if the infant experiences an SAE associated with such a drug, the SAE is reported together with the exposure during breastfeeding.
Here’s the clear part of this, that everyone can understand:
184.108.40.206. Occupational Exposure An occupational exposure occurs when a person receives unplanned direct contact with the study intervention, which may or may not lead to the occurrence of an AE. Such persons may include healthcare providers, family members, and other roles that are involved in the trial participant’s care. The investigator must report occupational exposure to Pfizer Safety within 24 hours of the investigator’s awareness, regardless of whether there is an associated SAE. The information must be reported using the Vaccine SAE Report Form. Since the information does not pertain to a participant enrolled in the study, the information is not recorded on a CRF; however, a copy of the completed Vaccine SAE Report Form is maintained in the investigator site file.
I WILL TRANSLATE THAT TO ENGLISH:
An occupational exposure occurs when a person receives unplanned direct contact with a vaccine test subject, which may or may not lead to the occurrence of an adverse event. These people may include health care providers, family members, and other people who are around the trial participant.
When such exposures happen, the investigator must report them to Pfizer saftey within 24 hours of becoming aware of when they happened, regardless of whether or not there is an associated secondary adverse event. This must be reported using the vaccine secondary adverse event report form. SINCE THE INFORMATION DOES NOT PERTAIN TO A PARTICIPANT INVOLVED IN THE STUDY, THE INFORMATION WILL BE KEPT SEPARATE FROM THE STUDY.
(Natural News) Not surprisingly, everything the establishment tells us about covid vaccines has been a calculated lie. One of the biggest and most treacherous lies is that “mRNA vaccine shots stay in the arm and don’t circulate nanoparticles around the body.” Now we know that is a complete lie, as new research conducted in Japan shows that Lipid NanoParticles (LNPs) containing the mRNA code are widely circulated around the body after vaccination, reaching the brain, spleen, large intestine, heart, liver, lungs and other organs.
The study paper, originally written in Japanese and auto-translated into English, can be found at this link on Natural News servers (PDF).
Labeled, “Pfizer confidential,” the study is known as a bio-distribution study that uses luciferase enzymes and radioisotope markers to accurately track the distribution of Pfizer’s mRNA LNPs across the body. The first section is labeled:
SARS-CoV-2 mRNA Vaccine (BNT162, PF-07302048)
2.6.4 Summary of pharmacokinetic study
The study reveals how mRNA LNPs are distributed across the body, even affecting ovaries and testes, raising huge questions about fertility in those receiving mRNA vaccine shots.
What are Spike Proteins?
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus behind the worldwide outbreak of COVID-19 disease. One of the key biological characteristics of SARS-CoV-2, as well as several other viruses, is the presence of spike proteins that allow these viruses to penetrate host cells and cause infection.
Image Credit: MattLphotography/Shutterstock.com
An overview of the coronavirus structure
Coronaviruses (CoVs) like the Middle East respiratory syndrome (MERS)-CoV, which had infected almost 2,500 individuals by the end of 2019, as well as the novel severe acute respiratory syndrome (SARS)-CoV-2, are enveloped and spherical viruses that typically measure between 80 and 120 nanometers (nm) in size.
The RNA genome of coronaviruses, which, at a median length of 29 kb is the longest among all RNA viruses, is comprised of six to ten open reading frames (ORFs) that are responsible for encoding both the replicase and structural proteins for the virus.
Each of the components of the viral genome is packaged into a helical nucleocapsid that is surrounded by a lipid bilayer.
The viral envelope of coronaviruses is typically made up of three proteins that include the membrane protein (M), the envelope protein (E), and the spike protein (S).
Image Credit: Orpheus FX/Shutterstock.com
Spike protein functions
The S protein is a highly glycosylated and large type I transmembrane fusion protein that is made up of 1,160 to 1,400 amino acids, depending upon the type of virus.
As compared to the M and E proteins that are primarily involved in virus assembly, the S protein plays a crucial role in penetrating host cells and initiating infection.
Notably, the presence of S proteins on the coronaviruses is what gives rise to the spike-shaped protrusions found on their surface.
S proteins of coronaviruses can be divided into two important functional subunits, which include the N-terminal S1 subunit, which forms the globular head of the S protein, and the C-terminal S2 region that forms the stalk of the protein and is directly embedded into the viral envelope.
Upon interaction with a potential host cell, the S1 subunit will recognize and bind to receptors on the host cell, whereas the S2 subunit, which is the most conserved component of the S protein, will be responsible for fusing the envelope of the virus with the host cell membrane.
How S protein allows coronaviruses to enter cells
Once the S1 subunit binds to host cell receptors, two major conformational changes must occur for the S2 subunit to complete the fusion of the virus to the cell membrane. The two components of the S2 subunit that are involved in the coronavirus fusion include heptad repeat (HR) regions one and two, otherwise referred to as HR1 and HR2.
The first conformation otherwise referred to as pre-hairpin, involves the transformation of an unstructured linker within the S2 subunit to become helical. The second conformational change to occur involves the inversion of this subunit’s C-helix to the coil, resulting in the formation of a six-helix bundle.
Once these conformations are completed, the fusion peptide is anchored to the membrane of the host cell to allow the virus to move closer towards the cell membrane and eventually deliver the nucleocapsid to the target cell.
Targeting viruses via the S protein
Without the S protein, viruses like the novel SARS-CoV-2 would not be able to interact with the cells of potential hosts like animals and humans to cause infection. As a result, the S protein represents an ideal target for vaccine and antiviral research endeavors.
In addition to its role in penetrating cells, the S protein of viruses, particularly the SARS-CoV-2 virus, is a major inducer of neutralizing antibodies (NAbs). NAbs are protective antibodies that are naturally produced by our humoral immune system.
To elicit their antiviral activity, NAbs bind to the surface epitopes of viral particles to prevent their entry into a host cell. Some of the NAbs that have been identified against SARS-CoV include 80R, CR3014, and CR3022, all of which specifically target the S1 domain.
The sensitivity of the S protein of SARS-CoV-2 to these NAbs has led many researchers to be interested in developing standardized agents that can block the binding and fusion of the S protein of SARS-CoV-2 to host cells.
Although one recent study has found that the neutralization capability of CR3022 against the SARS-CoV-2 region binding domain (RBD) within the S1 subunit is uncertain, another study on both Ebola and SARS viruses has found that a cocktail of NAbs has stronger neutralization capabilities as compared to when these NAbs are given alone.
This information, therefore, leads researchers to believe that a combination of several potent NAbs has the potential to target SARS-CoV-2 and increase its sensitivity to neutralization.